Closed Loop DBS for Parkinson’s disease using a Cochlear stimulator

Currently, DBS is ‘open loop’ - stimulation is set at the same level regardless of what the patient is doing. This means that at any particular moment, stimulation may be excessive or insufficient, resulting in side effects or incomplete benefit. We are therefore investigating ‘closed loop’ stimulation – where DBS is applied according to need, triggered by brain signal that reflect disease severity. This requires a sophisticated device to sense these signals and deliver stimulation at high resolution. This may be achieved by the advanced electronics used in Cochlear stimulators. A further advantage of Cochlear devices is their small size, which may allow implantation directly in the skull bone rather than in the chest wall.

Collaborators: Bionics Institute, Australia Pacific Centre of Neuromodulation, University of Oxford

Funders: Colonial Foundation

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